Interaction between PPI and clopidogrel

Here, I have read a good article which I would like to be share:
Issue regarding interaction between PPI and clopidogrel.

It's often that we will see clopidogrel is given together with PPI, but the concern is the interaction. If you check in the micromedex, the interaction is major.

Is the interaction really an issue? This article is a latest clinical study (2012) carried out to study the interaction between these 2 groups of medications. The conclusion of this study suggested that the interaction between proton pump inhibitors and clopidogrel is clinically unimportant.

http://www.bmj.com/content/345/bmj.e4388.pdf%2Bhtml

This article may be helpful when your prescriber queries about this issue.

 

Anyway, in practice, we can counsel patient to seperate the administration of these 2 medications, one in the morning, the other one in the evening.

P/s: this is for sharing purpose.